The early steps in corticogenesis are decisive for the correct unfolding of neurogenesis, neuronal migration and differentiation ...
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The early steps in corticogenesis are decisive for the correct unfolding of neurogenesis, neuronal migration and differentiation under tight genetic control. In this monograph, the author outlines the main events in human preplate formation according to their timetable of appearance and the expression of developmentally relevant gene products. Also examined are the gradual transformation of the preplate into the cortical plate, and the establishment of the transient compartments of the foetal cortical wall. Contenu 1 Introduction.- 2 Materials and Methods.- 3 The anatomical basis of human cortical development.- 4 Neuronal migration.- 5 Compartments of the cortical wall.- 6 The cortical hem. Signalling center and birthplace of Cajal-Retzius cells.- 7 The Reelin-Dab1 signaling pathway.- 8 Cdk5/p35.- 9 LIS1 and DCX: Key genes for neuronal migration and cortical folding.- 10 Arx: A novel type of lissencephaly.- 11 Final considerations: The unique features of human cortical development.- 12 References
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Genetic Control of Neuronal Migrations in Human Cortical Development